Epigenetics of the yeast galactose genetic switch.
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2009-10
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Abstract
The transcriptional activation of enzymes involved in galactose utilization (GAL genes) in Saccharomyces cerevisiae
is regulated by a complex interplay between three regulatory proteins encoded by GAL4 (transcriptional activator),
GAL3 (signal transducer) and GAL80 (repressor). The relative concentrations of the signal transducer and the repressor
are maintained by autoregulation. Cells disabled for autoregulation exhibit phenotypes distinctly different from that
of the wild type cells, enabling us to explore the biological signifi cance of autoregulation. The redundancy in signal
transduction due to the presence of GAL1 (alternate signal transducer) also makes it a suitable model to understand the
phenomenon of epigenetics. In this article we review some of the recent attempts made to understand the importance
of epigenetics in the establishment of cellular and transcriptional memory.
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Bhat Paike Jayadeva, Iyer Revathi S. Epigenetics of the yeast galactose genetic switch. Journal of Biosciences. 2009 Oct; 34(4): 513-522.