Tumor necrosis factor–alpha in the development of insulin resistance in type 2 diabetes mellitus.
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Date
2011-01
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Abstract
Obesity and Insulin resistance are very frequent disorders and are
described as the dominant risk factors for cardiovascular diseases. Recent research
suggests that TNF-alpha, an adipocytokine plays a key role in the development of insulin
resistance. Aim of the study was to estimate TNF-alpha levels and to investigate the
association of TNF-alpha with the various factors associated with insulin resistance like Body
mass index, Waist Hip Ratio, fasting insulin etc. A total of 100 subjects attending out
patient department of General Medicine , Narayana Medical College , Nellore were
selected for the study.50 patients were diagnosed as type-2 diabetics and 50 subjects were
taken as normal healthy controls who attended for a general check-up. Anthropometric
and biochemical measurements were analyzed. Serum Insulin and TNF-α were measured
using chemiluminescence method and ELISA method respectively. Homeostasis model
assessment score was used to gauge the level of insulin resistance. Our Results showed
significant elevation in TNF-alpha levels in diabetic subjects and correlations between TNFalpha
Body Mass Index and HOMAIR were significant. All correlations were stronger for
females compared to males.
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Keywords
TNF-alpha, Insulin Resistance, Type-2 Diabetes Mellitus
Citation
Rajarajeswari D, Ramalingam K, Naidu J N. Tumor necrosis factor–alpha in the development of insulin resistance in type 2 diabetes mellitus. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jan-Mar; 2(1): 55-60.