Studies on immunomodulatory activity of Aloe vera (Linn).
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Date
2011-01
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Abstract
To study the immunomodulatory activity of saline extracts of leaves of Aloe vera Linn.
(Family: Liliaceae) on the albino mice. The saline extract of leaves of Aloe vera was administered orally
according to their body weight in mice. The assessment of immunomodulatory activity on specific and
nonspecific immunity was studied by administration of test extract. The method of pyrogallol induced
immunosupression was employed with slight modification to study the immunomodulatory potential of
the extract. Humoral antibody response to SRBC measurement of antibody titer by haemagglutination
reaction was done and cellular immune response (Foot pad reaction test) the edema was induced in the
right paw of mice by injecting SRBC (0.025x109 cells) in the sub planar region. Pyrogallol-induced
suppression of humoral as well as cell mediated immune response was significantly attenuated by daily
oral treatment with saline extract of Aloe vera. Vitamin E treated group exhibited similar attenuation of
the suppression in immune responses. Aloe vera extract at the dose of 100 mg/kg was found to suppress
delayed type hypersensitivity reaction induced by SRBCs in mice. As evidenced by marked increase in
haemagglutination titers in mice was also observed. The study demonstrates that A. vera triggers both
specific and non-specific responses to a greater extent. The study comprised the acute toxicity and
preliminary phytochemical screening of A. vera. From the results obtained and phytochemical studies the
immunostimulant effect of Aloe vera could be attributed to the alkaloids content.
Description
Keywords
Immunomodulatory activity, Aloe vera, Haematological, Serological studies
Citation
Chandu Atul N, Kumar C Santhosh, Bhattacharjee Chiranjib, Debnath Subal, Kannan K Kamala. Studies on immunomodulatory activity of Aloe vera (Linn). International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jan-Mar; 2(1): 19-22.