Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis.
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2009-03
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Abstract
Human papillomavirus (HPV) is small, double-stranded DNA virus that infects mucosal and cutaneous epithelial
tissue. HPV is sexually transmitted and the viral DNA replicates extrachromosomally. The virus is non-enveloped and
has an icosahedral capsid. There are approximately 118 types of HPV, which are characterized as high-risk or lowrisk
types. High-risk HPVs cause malignant transformation while the low-risk ones cause benign warts and lesions.
The expression of E6 and E7 is normally controlled during the normal viral life cycle when viral DNA replicates
extrachromosomally. HPV E6 and E7 oncoproteins are overexpressed when the viral genome integrates into the host
DNA. Deregulated overexpression of E6 and E7 oncoproteins can cause several changes in cellular pathways and
functions leading to malignant transformation of cells and tumorigenesis. In this review, we focus on several cellular
mechanisms and pathways that are altered in the presence of E6 and E7, the target proteins of E6 and E7 inside the
host cell and how they contribute to the development of the transformed phenotype.
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Ganguly Niladri, Parihar Suraj P. Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis. Journal of Biosciences. 2009 Mar; 34(1): 113-123.