Frequency and potential application of HLA antibodies from pregnant women in Mumbai.
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Date
1998-12
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Abstract
Antenatal sera from 1334 pregnant women attending the Nowrojee B J Wadia Maternity Hospital and KEM
Hospital in Parel, Mumbai were collected and screened for anti HLA A and B antibodies to produce an
indigenous HLA tissue typing tray. One hundred and sixty three sera (12.2%) were found positive for HLA
antibodies. Nonetheless, the percentage of positive sera were almost the same in women of different parity.
Moreover, the incidence of anti-HLA antibodies was correlated with the allelic frequencies in the Maharastrian
population. Thus in India, collection and screening of sera from pregnant females is a simple and cost-effective
method of acquiring polyclonal sera for routine use in tissue typing.
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Shankarkumar U, Gupte S C, Gupte S S, Pednekar S V, Ghosh K, Mohanty D. Frequency and potential application of HLA antibodies from pregnant women in Mumbai. Journal of Biosciences. 1998 Dec; 23(5):601-604.