Chronobiotic effect of melatonin following phase shift of light/dark cycles in the field mouse Mus booduga.
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Date
1996-12
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Abstract
The objective of this study was to assess whether melatonin accelerates the reentrainment
of locomotor activity after 6 h of advance and delay phase shifts following exposure
to LD 12:12 cycle (simulating jet-lag/shift work). An experimental group of adult male field
mice Mus booduga were subjected to melatonin (1 mg/kg) through i.p. and the control group were
treated with 50 % DMSO. The injections were administered on three consecutive days following
6h of phase advance and delay, at the expected time of "lights off'. The results show that
melatonin accelerates the re-entrainment after phase advance (29%) when compared with
control mice. In the 6 h phase delay study, the experimental mice (melatonin administered) take
more cycles for re-entrainment (51%) than the control. Further, the results suggest that though
melatonin may be useful for the treatment of jet-lag caused by eastward flight (phase advance) it
may not be useful for westward flight (phase delay) jet-lag.
Description
Keywords
Melatonin, re-entrainment, circadian rhythm, locomotor activity, Mus booduga
Citation
Singaravel M, Sharma V K, Subbaraj R, Nair N Gopukumar. Chronobiotic effect of melatonin following phase shift of light/dark cycles in the field mouse Mus booduga. Journal of Biosciences. 1996 Dec; 21(6): 789-795.