Insights into mechanism of tumour promotion by mezerein.
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Date
1996-06
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Abstract
The objective of this study was to gather insights and compare the mode of action of
the non phorbol, diterpene mezerein with the phorbol ester, phorbol-12-myristate-13 acetate, in
normal and transformed cells. Both phorbol-12-myristate-13 acetate and mezerein are shown to
activate the signal transduction pathways involving post translational modification of proteins by
poly ADP-ribosylation and by protein kinase C, but to varying extents and showed different time
kinetics and cell type differences.Multiple nuclear proteins, especially histones H3d, A24 and HI
served as acceptors of poly ADP-ribose in response to PMA in both NIH 3T3 and HDCS cells
whereas H1 and H2B were the major acceptors in case of mezerein treatment, similarly in both
NIH 3T3 and HDCS cells. The results suggest an epigenetic mechanism (s) in tumour promotion
by mezerein.
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Keywords
Tumour promotion, mezerein, ADP-ribosylation, protein kinase C
Citation
Rudra Nandini, Singh Neeta, Gupta Malaya. Insights into mechanism of tumour promotion by mezerein. Journal of Biosciences. 1996 Jun; 21(4): 477-485.