Enhanced MHC I antigen expression on tumour target cells is inversely correlated to lysis by allogenic but not by xenogenic NK cells.
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Date
1995-09
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Abstract
Relationship between the levels of MHC class 1 antigen expressed on tumour
cells and their susceptibility to allogenic and xenogenic NK cells was investigated. Mouse
and human natural killer-resistance inducing factor (NK-RIF) preparations were used for
augmenting/inducing MHC 1 antigen expression on murine YAC and human K562 tumour
cells, respectively YAC cells with augmented MHC I antigen expression became relatively
resistant to lysis by murine NK cells but not to rat NK cells. Similarly, induction of MHC
I antigens on K562 cells reduced their susceptibility to human NK cells but not to monkey
NK cells. These results indicate that the inverse correlation of MHC I antigen expression
and NK susceptibility does not hold true for xenogenic pairs of NK effector and target
cells.
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Keywords
NK cells, MHC antigens, tumour cells, natural killer-resistance inducing factor, xenogenic targets
Citation
Sarin A, Saxena Q B, Herberman R B, Saxena R K. Enhanced MHC I antigen expression on tumour target cells is inversely correlated to lysis by allogenic but not by xenogenic NK cells. Journal of Biosciences. 1995 Sep; 20(4): 515-523.