Valacyclovir: Development, treatment and pharmacokinetics.
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Date
2010-11
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Abstract
Acyclovir a specific and selective inhibitor of herpes virus has been used safely and
effectively. The bioavailability of the drug is low results in poor absorption of drug. Valacyclovir
is the L- valyl ester prodrug of Acyclovir. It is used in the treatment of Herpes simplex virus and
Varicella zoster virus. After oral administration it is rapidly converted to acyclovir in the Gastro
intestinal tract and liver, which increases the bioavailability of acyclovir three to five times that
of acyclovir alone.
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Keywords
Valacyclovir, Development, Treatment and Pharmacokinetics
Citation
Pradeep B, Nagamadhu M, Banji David, Shekhar K, Madhavi B Bindu, Arjun G. Valacyclovir: Development, treatment and pharmacokinetics. International Journal of Applied Biology and Pharmaceutical Technology. 2010 Nov-Dec; 1(3): 1076-1083.