Relationship between glycerol-3-phosphate dehydrogenase, fatty acid synthase and fatty acid binding proteins in developing human placenta.
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Date
1995-03
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Abstract
The activities of the enzymes glycerol-3-phosphate dehydrogenase and fatty acid
synthase are inhibited by palmitoyl-coenzyme A and oleate. The two isoforms of fatty acid
binding proteins (PI 6·9 and PI 5·4) enhance the activities of glycerol-3-phosphate
dehydrogenase and fatty acid synthase in the absence of palmitoyl-coenzyme A or oleate
and also protect them against palmitoyl-coenzyme A or oleate inhibition. Levels of fatty
acid binding proteins, the activities of the enzymes fatty acid synthase and glycerol-3-phosphate
dehydrogenase increase with gestation showing a peak at term. However, the activity of
fatty acid synthase showed the same trend up to the 30th week of gestation and then
declined slightly at term. With the advancement of pregnancy when more lipids are required
for the developing placenta, fatty acid binding proteins supply more fatty acids and
glycerol-3-phosphate for the synthesis of lipids. Thus a correlation exists between
glycerol-3-phosphate dehydrogenase, fatty acid synthase and fatty acid binding proteins in
developing human placenta.
Description
Keywords
Glycerol-3-phosphate dehydrogenase, fatty acid nthase, ontogeny, placenta
Citation
Bandyopadhyay Anup K, Das Tanya, Sa Gouri Sankar, Mukherjea Manju. Relationship between glycerol-3-phosphate dehydrogenase, fatty acid synthase and fatty acid binding proteins in developing human placenta. Journal of Biosciences. 1995 Mar; 20(2): 141-149.