Frequency of HLA antibodies in south India.
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Date
1993-09
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Abstract
Sera from 4088 pregnant women (649 antenatal bleeding and 3439 post-partum
bleeding) living in Madurai, were collected and screened for anti-HLA. Α, Β and DR
antibodies. 696 of them were screened for anti-HLA DR antibodies. Ten per cent (65/649)
of antenatal sera and 13·4% of post-partum sera (463/3439) were positive for HLA A and
Β antibodies: nonetheless the percentage of monospecific sera were almost the same in
both. Screening for HLA DR antibodies were carried out using platelet absorption in test
tray technique: seventy three of 696 (10·5%) were positive. The incidence of anti-HLA A, B
antibodies correlates to the allelic frequencies in the population. Thus in India, collection
and screening post-partum haemorrhage is the simplest and cost effective method of
acquiring polyclonal sera for routine laboratory and diagnostic use.
Description
Keywords
HLA, anti-HLA antibodies, post-partum, pregnancy
Citation
Pitchappan R M, Amutha S, Mahendran V, Brahmajothi V, Kumar U Shankar, Balakrishnan K, Kumari R Shantha, Sashidhar M, Amairaj S, Manuel May, Raja V Indra. Frequency of HLA antibodies in south India. Journal of Biosciences. 1993 Sept; 18(3): 373-380.