Protective effect of glutathione and selenium against alloxan induced lipid peroxidation and loss of antioxidant enzymes in erythrocytes.
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Date
1994-03
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Abstract
Alloxan is a diabetogenic drug and is known to induce diabetes through
generation of free radicals. The toxic oxygen species can be detoxified by antioxidant
enzyme system and thus reduce the deleterious effect of lipid peroxidation. Erythrocytes
exposed to alloxan induced lipid peroxidation in vivo as well as in vitro. Although alloxan
treatment produced a deleterious effect on antioxidant enzymes, pretreatment with glutathione
and selenium led to a recovery of the activities of superoxide dismutase and glutathione
peroxidase. However, catalase activity increased on alloxan treatment. Alloxan reduced
blood glucose level significantly within 60 min but thereafter a slow and steady rise was
observed.
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Keywords
Lipid peroxidation, superoxide dismutase, catalase, glutathione peroxidase, alloxan
Citation
Yadav Poonam, Sarkar S, Bhatnagar D. Protective effect of glutathione and selenium against alloxan induced lipid peroxidation and loss of antioxidant enzymes in erythrocytes. Journal of Biosciences. 1994 Mar; 19(1): 19-25.