Specificity in the regulation of eukaryotic gene transcription.
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Date
1993-03
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Abstract
The regulation of eukaryotic gene transcription poses major challenges in terms
of the innumerable protein factors required to ensure tissue or cell-type specificity. While
this specificity is sought to be explained by the interaction of cis-acting DNA elements and
the trans-acting protein factor(s), considerable amount of degeneracy has been observed in
this interaction. Immunoglobulin heavy chain gene expression in Β cells and liver-specific
gene expression are discussed as examples of this complexity in this article.
Heterodimerization and post-translational modification of transcription factors and the
organization of composite promoter elements are strategies by which diverse sets of genes
can be regulated in a specific manner using a finite number of protein factors.
Description
Keywords
Transcription in eukaryotes, regulation
Citation
Padmanaban G. Specificity in the regulation of eukaryotic gene transcription. Journal of Biosciences. 1993 Mar; 18(1): 27-36.