Tissue distribution and antileishmanial activity of liposomised Amphotericin-B in Balb/c mice§.
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Date
1991-12
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Abstract
Antileishmanial activity and organ distribution of the antifungal drug
Amphotericin-B in free and liposomised form have been studied in Balb/c mice infected
with Leishmania donovani. Results indicate that Amphotericin-B in the liposomised form is
significantly more active than the free form. This increase in the activity is perhaps related
to the reduced drug toxicity rather than the altered drug distribution at the site of
infection.
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Keywords
Amphotericin-B, antileishmanial activity, renal toxicity, liposomes, tissue distribution, drug delivery
Citation
Ahmad Imran, Agarwal Anshu, Pal Ajay, Guru P Y, Bachhawat B K, Gupta C M. Tissue distribution and antileishmanial activity of liposomised Amphotericin-B in Balb/c mice§. Journal of Biosciences. 1991 Dec; 16(4): 217-221.