Immunoprophylaxis against filarial parasite, Brugia malayi: potential of excretory-secretory antigens in inducing immunity.
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Date
1991-12
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Abstract
The role of excretory-secretory antigens in inducing immunity in the host
against Brugia malayi microfilariae and infective larvae was studied by in vitro antibody
dependent cell-mediated reaction as well as in vivo inoculation of filarial parasites within a
microchamber in the host. The immune sera of jirds raised against Brugia malayi
microfilarial and infective larval excretory-secretory antigens (Bm Mf ESA and Bm L3
ESA) promoted the adherence of peritoneal exudate cells to Brugia malayi microfilariae
and infective larvae in vitro and induced cytotoxicity to the parasites within 48 h. The anti
Bm Mf ESA serum was more effective than anti Bm L3 ESA serum in inducing cytotoxicity
to microfilariae and both antisera had a similar cytotoxic effect on infective larvae. In the
microchambers implanted in the immune jirds, host cells could migrate and adhere to the
microfilariae and infective larvae and kill them within 48–72 h. Further, Mastomys
natalensis immunized against Bm Mf ESA and L3 ESA generated a high degree of
protective response against circulating microfilariae. These results suggest that excretorysecretory
antigens are effective in inducing resistance against filarial parasites and thus
have potential in immunoprophylaxis.
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Keywords
Brugia malayi, microfilariae, infective larvae, immunoprophylaxis, excretorysecretory antigens
Citation
Cheirmaraj K, Chenthamarakshan V, Reddy M V R, Harinath B C. Immunoprophylaxis against filarial parasite, Brugia malayi: potential of excretory-secretory antigens in inducing immunity. Journal of Biosciences. 1991 Dec; 16(4): 209-216.