Optimization of sodium orthovanadate to treat streptozotocin-induced diabetic rats.
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Date
1990-06
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Abstract
Oral administration of sodium orthovanadate restored blood glucose to normal
levels in streptozotocin-induced diabetic rats. To establish the safety dose and to evaluate
the side effects of over dose, if any, different doses of vanadium were used in the present
study. Low concentrations of vanadium (0·1 and 0·3 mg/ml in drinking water) restored
blood glucose, urea, cholesterol and the status of liver pathophysiological enzymes to
normal levels in experimental rats. High vanadate treatment proved to be toxic not only to
diabetic but also to normal rats as evidenced from the observations on the blood urea,
plasma and liver glutamate oxaloacetate transaminase and glutamate pyruvate
transaminase. Low vanadate treatment restored body homeostasis of diabetic rats and was
found to be nontoxic to normals.
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Keywords
Vanadate optimization, diabetes, lipid peroxidation
Citation
Sekar N, Willam S, Balasubramaniyam N, Kamarajan P, Govindasamy S. Optimization of sodium orthovanadate to treat streptozotocin-induced diabetic rats. Journal of Biosciences. 1990 Jun; 15(2): 67-75.