Effect of doxorubicin on the intestinal membranes in rats—Influence of α-tocopherol administration.
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Date
1990-03
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Abstract
The effect of α-tocopherol on doxorubicin induced changes in intestinal brush
border and basolateral membranes were studied in rats. Rats were treated with doxorubicin
(2·5 mg/kg body wt.), intravenously, weekly for 8 weeks. α-Tocopherol (400 mg/kg body wt.)
was given orally, daily for 2 months. Intestinal basolateral membrane bound ATPases and
brush border membrane bound alkaline phosphatase activities were found to be decreased
significantly in doxorubicin treated rats. The lipid peroxide level was found to be elevated
with a significant depletion in membrane sulphydryl groups. In α-tocopherol coadministered
animals, the enzyme activities were found to be restored with concomitant
reduction in lipid peroxide levels and an increase in the membrane sulphydryl groups. The
membrane cholesterol and phospholipid levels which were altered in doxorubicin treated
animals were found to be maintained significantly. The results are discussed with reference
to the effect of α-tocopherol on lipid peroxidation and membrane sulphydryl groups.
Description
Keywords
Doxorubicin, intestine, basolateral membrane, brush border membrane, ATPases, alkaline phosphatase, sulphydryl groups, α-tocopherol, antioxidant
Citation
Geetha A, Sankar R, Marar Thankamani, Devi C S Shyamala. Effect of doxorubicin on the intestinal membranes in rats—Influence of α-tocopherol administration. Journal of Biosciences. 1990 Mar; 15(1): 31-36.