Transplantation of fetal neocortex in rhesus monkey.
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Date
1989-09
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Abstract
A feasibility study of neural transplantation in adult rhesus monkey was
undertaken. Fresh and preserved neocortex containing multiplying and maturing neurons
obtained from 55-70 gestation days were transplanted into the striatum, cerebellum and
cerebral cortex of adult monkeys. Tissues were preserved for 4 days either at subzero
temperature in the freezer compartment of the ordinary refrigerator in Ringer lactate or
incubated in culture medium. While 2 monkeys out of 5 injected with preserved tissue had
successful transplants after 4 months, all the 10 monkeys injected with fresh tissue had no
transplants. The size of the two surviving transplants was small. The neurons in the
transplants were mainly in clusters. Many of the cells were immature and some showed
early degenerative changes. Neuronal processes were restricted to the transplants and thus
showed lack of morphological integration with the host tissue. Further studies are in
progress to define the nature of the embryonic tissue of primate which can grow and
survive and also the role of neural grafts in functional recovery following experimental
lesions of the brain regions.
Description
Keywords
Rhesus monkey, fetal neocortex, neural transplantation
Citation
Parthasarathy L, Ramesh T G, Devi C S Shyamala, Parthasarthy R. Transplantation of fetal neocortex in rhesus monkey. Journal of Biosciences. 1989 Sep; 14(3): 255-260.