Modulation of ovarian ornithine decarboxylase activity during follicular differentiation/maturation.
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Date
1989-06
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Abstract
The role of gonadotropins and estrogen on the regulation of ovarian ornithine
decarboxylase was studied during follicular differentiation/maturation. In intact immature
rats follicular differentiation/maturation was initiated with sequential administration of
estrogen and follicle stimulating hormone. Ornithine decarboxylase activity in response to
human chorionic gonadotropin was markedly enhanced (2-fold) in rats with preovulatory
antral follicles when compared to rats with non-ovulatory follicles. This increase could be
attributed to the alteration in the turnover of the enzyme. Following follicle maturation
the half life of the human chorionic gonadotropin stimulated ornithine decarboxylase was
increased from 18 to 62 min. This increase in half life was associated with differentition of
follicles. In the estrogen treated group (which does not induce follicular differentiation), the
half life of the enzyme remained unaltered. The regulation of ornithine decarboxylase
through the formation of protein inhibitor antizyme induced by diamino hexane, was
unaltered during follicular differentiation.
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Keywords
Ovarian ornithine decarboxylase, follicular maturation, half life, antizyme
Citation
Natraj Usha. Modulation of ovarian ornithine decarboxylase activity during follicular differentiation/maturation. Journal of Biosciences. 1989 Jun; 14(2): 101-109.