Interaction and in vivo growth inhibition of Ehrlich ascites tumor cells by jacalin.
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Date
1988-12
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Abstract
Jacalin has been found to agglutinate Ehrlich ascites cells. The agglutination
was inhibited by a-glycosides of D-Gal and ß -D-Gal(1 → 3)-D-GalNAc suggesting that the
lectin-ascites interaction was carbohydrate-specific. There was 21·8% inhibition of tumour
(ascites) cell growth in vivo in mice administered 50μg of jacalin by injection for 6 days
following intraperitoneal injection of ascites cells. Administration of 100, 150 and 200 μg
jacalin resulted in 40·2, 57·5 and 83% inhibition respectively. The in vivo inhibition of
tumour cells growth by jacalin was due to its preferential binding with D-Gal-a -( 1→6)
present as terminal residues in the glycoprotein on tumour cell surface.
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Keywords
Ehrlich ascites cells, jacalin, jackfruit lectin, Griffonia simplicifolia, lectin
Citation
Ahmed H, Chatterjee B P, Debnath A K. Interaction and in vivo growth inhibition of Ehrlich ascites tumor cells by jacalin. Journal of Biosciences. 1988 Dec; 13(4): 419-424.