Effects of piretanide on plasma fibrinolytic activity, platelet aggregation and platelet factor-4 release in man.
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Date
1986-06
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Abstract
Piretanide, 4-phenoxy-3-(pyrrolidinyl)-5-sulphamoyl benzoic acid, apart from
being an efficient diuretic, enhances endogenous plasma fibrinolytic activity after a single dose of
6 mg administered by oral route. After ingestion of the drug, acceleration of fibrinolytic
acitivity became manifest within 1 h, reached its peak in 3 h and was associated with a fall in
fibrinogen and diminished urokinase excretion. Piretanide did not cause lysis of fibrin in vitro.
Primary platelet aggregation, induced by adenosine-diphosphate, was inhibited by piretanide.
In in vitro experiments piretanide led to effective inhibition of adenosine-diphosphate-induced
platelet aggregation with complete inhibition at 5 mM concentration. Piretanide led to a highly
significant decrease of platelet factor-4 release.
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Keywords
Piretanide, synthetic fibrinolytic agent, anti-platelet agent, PF-4 release, diuretic
Citation
Chohan I S. Effects of piretanide on plasma fibrinolytic activity, platelet aggregation and platelet factor-4 release in man. Journal of Biosciences. 1986 June; 10(2): 243-249.