N-[2-Naphthyl]-glycine hydrazide, a potent inhibitor of DNAdependent RNA polymerase of Mycobacterium tuberculosis H37Rv.
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Date
1986-03
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Abstract
N-[2-Naphthyl]-glycine hydrazide has been shown for the first time as a potent
inhibitor of the DNA-dependent RNA polymerase (EC 2.7.7.6) of Mycobacterium tuberculosis
H37Rv. At a concentration of 10–9 M, the compound shows maximum inhibition of the
enzyme, the inhibition being less at higher concentrations. It is suggested that the novel type of
inhibition pattern may be due to hydrophobic interactions occurring between the molecules
of the compound at higher concentrations. The finding that there is a shift in the λmax of
the compound could also account for this phenomenon. The effect of this compound was also
tested on DNA-dependent RNA polymerases from an eukaryotic fungus, Microsporum canis.
At a concentration of 10–9 Μ it inhibits RNA polymerase II (32%) but not RNA
polymerases I and III.
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Keywords
N-[2-Naphthyl]-glycine hydrazide, Mycobacterium tuberculosis, Microsporum canis, RNA polymerase
Citation
Prabhu Rekha, Rao G Ramananda, Jamaluddin M, Shnan T Ramakri. N-[2-Naphthyl]-glycine hydrazide, a potent inhibitor of DNAdependent RNA polymerase of Mycobacterium tuberculosis H37Rv. Journal of Biosciences. 1986 Mar; 10(1): 163-166.