Biological characteristics of the peptides a and β isolated from bovine seminal plasma.
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Date
1987-12
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Abstract
The bull seminal plasma peptides a and β have been examined for their
biological properties. While both the peptides were able to inhibit the human chorionic
gonadotropin-dependent uterine response in the mouse, a alone exhibits the property of
suppressing post-castrational rise in gonadotropin in appropriate animal models. This
suggests that the peptide β must be acting directly on the ovary to suppress estrogen
production and, consequently, the uterine weight increase. Such a possibility was confirmed
when a and β were examined by the coupled bioassay which is capable of discriminating
between pituitary feedback factors and those acting directly on the gonad. In a test system
designed to examine chronic effects, both a and β showed evidence of acting directly on the
ovary to inhibit human menopausal gonadotropin-induced estrogen production. Such a direct
action could not be correlated with the relative potencies of these peptides when examined
for their follicle stimulating hormone-receptor binding inhibitor and lutinizing hormonereceptor
binding inhibitor activities.
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Keywords
Seminal plasma peptides, inhibin activity, extra-pituitary action
Citation
Chari S, Mohapatra S K, Duraiswami S. Biological characteristics of the peptides a and β isolated from bovine seminal plasma. Journal of Biosciences. 1987 Dec; 12(4): 359-365.