Structural organization of cholera toxin gene and its expression in an environmental non-pathogenic strain of Vibrio cholerae.
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Date
1987-03
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Abstract
Non-pathogenic, environmental strain of Vibrio cholerae, ELTOR Ogawa EW6
carries a copy of the cholera toxin gene in its chromosome. Restriction enzyme digestion
followed by Southern blot analysis revealed that the structure of the cholera toxin gene in
this organism is different from that found in the virulent strains. The xbaI site which has
been found to be conserved in the cholera toxin of the virulent strains examined so far, is
absent here. Results of the RNA dot blot analysis indicated that the cholera toxin gene in
EW6 is transcribed much less efficiently compared to the cholera toxin gene present in the
virulent strain Vibrio cholerae classical Inaba 569B.
Description
Keywords
Vibrio cholerae, avirulent strain, toxin gene
Citation
Bhattacharyya Uma, Ghosh Amit, Ghosh Ranajit K. Structural organization of cholera toxin gene and its expression in an environmental non-pathogenic strain of Vibrio cholerae. Journal of Biosciences. 1987 Mar; 11(1-4): 231-238.