Sharing of antigens among filarial species revealed by antibody dependent cell-mediated reactions.
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Date
1985-12
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Abstract
Antisera raised in albino rats against microfilariae of Litomosoides carinii, Brugia
pahangi, Brugia malayi and sera from Bancroftian elephantiasis patients promoted rat
neutrophil-mediated adherence and cytotoxicity to the microfilariae. Pre-treatment of the
immune sera, with microfilarial antigen at a final concentration of 5 and 25 μg per ml blocked
cellular adherence and cytotoxicity to the microfilariae indicating the presence of crossreactive
antibodies. The heterologous immune sera were effective in eliminating the circulating
Litomosoides carinii microfilariae in Mastomys natalensis.
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Keywords
Microfilariae, antigen, cross-reaction, antibody-dependent cellular cytotoxicity
Citation
Chandrashekar R, Rao U R, Subrahmanyam D. Sharing of antigens among filarial species revealed by antibody dependent cell-mediated reactions. Journal of Biosciences. 1985 Dec; 9(3&4): 191-196.