Novel tertiary structures and stereospecificities of periplasmic binding proteins involved in active transport and chemotaxis.
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Date
1985-08
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Abstract
Binding proteins, which are located in the periplasmic space of Gram-negative
bacteria, are essential components of osmotic shock-sensitive active transport systems and
Chemotaxis. Described briefly herein are the high resolution molecular structures of four
binding proteins specific for (i) L-arabinose, (ii) sulphate, (iii) D-galactose, and (iv) leucine,
isoleucine or valine which we have recently determined. The first three proteins contained
bound substrates. Several novel substrate binding properties of the arabinose- and sulphatebinding
proteins as revealed by structure refinement at 1·7 Å resolution are also presented.
These results have profound significance in understanding both protein structures and
substrate-protein interactions.
Description
Keywords
Binding proteins, X-ray structures, novel substrate protein complex
Citation
Quiocho F A, Vyas N K, Pflugrath J W, Saper M A, Vyas M N, Sack J S. Novel tertiary structures and stereospecificities of periplasmic binding proteins involved in active transport and chemotaxis. Journal of Biosciences. 1985 Aug; 8(1&2): 461-470.