Ca2+ and the interaction of pore-formers with membranes.
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Date
1985-08
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Abstract
The interaction of pore-forming agents, such as Sendai virus, influenza virus (at pH
5 3), activated complement, Staphylococcus aureus α-toxin, melittin and polylysine, with the
surface membrane of cells has been studied. In each case the following changes are initiated:
collapse of membrane potential, leakage of ions, and leakage of phosphorylated metabolites.
The changes can be inihibited by extracellular Ca2+ at physiological concentration; Mg2+ is
less effective, and Zn2+ is more effective, than Ca2+ Ca2+ appears to act at a stage subsequent
to the binding of pore-forming agent to cells. It is concluded that divalent cations are able to
protect cells against the damaging effects of certain viruses, toxins or the components of
activated complement in a manner that is worthy of further investigation.
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Keywords
Sendai virus, influenza virus, complement, melittin, toxin, permeability changes, membrane potential, Ca2+, Mg2+, Zn2
Citation
Pasternak C A, Bashford C L, Micklem K H. Ca2+ and the interaction of pore-formers with membranes. Journal of Biosciences. 1985 Aug; 8(1&2): 273-291.