Studies on ovarian quiescence in the lactating bonnet monkey (Macaca radiata).
Loading...
Date
1985-03
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Lactating bonnet monkeys were used as a model to understand the mechanism of
ovarian quiescence during lactation. The ovary of the bonnet monkey in the 3rd month of
lactation responds well to exogenous pregnant mare serum gonadotropin stimulation with
serum estrogen values reaching maximal levels by day 3 of the gonadotropin injection. The
adminstration of ovine prolactin to such monkeys significantly inhibited the ovarian
responsiveness to exogenous gonadotropin. The responsiveness of the pituitary of the
lactating monkey (in the 3rd month of lactation) to luteinizing hormone releasing hormone
injection was suppressed and supplementation with exogenous prolactin further accentuating
this effect. The relative ability of chlorpromazine given intravenously/intramuscularly/
intranasally to enhance endogenous prolactin levels was assessed. During the first 5 months
of lactation when the basal prolactin levels were high, the luteinizing hormone levels were low.
As the suckling stimulus reduces and prolactin levels fall, luteinizing hormone levels increase,
the first post-parturient mensus occurring by 218 ± 4 days. This event was postponed by 3
months on increasing endogenous prolactin levels by administering chlorpromazine
(250 μg/day by intranasal mode) over a 5 day period every month starting from the 3rd month
of lactation.
Description
Keywords
Lactational amennorrhea, hyperprolactinemia, ovary, luteinizing hormone, lacto lactogenic
Citation
Moudgal N R, Maneckjee R, Srinath B R, Ramasharma K. Studies on ovarian quiescence in the lactating bonnet monkey (Macaca radiata). Journal of Biosciences. 1985 Mar; 7(2): 95-103.