Involvement of peripheral noradrenaline and 5-hydroxytryptamine in carrageenin-induced pedal oedema in rats.
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Date
1984-09
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Abstract
Role of peripheral and central noradrenaline and 5-hydroxytryptamine in the
carrageenin-induced pedal oedema in rats was studied using agents which influence
catecholamine synthesis and receptor activity of noradrenaline and 5-hydroxytryptamine.
Reserpine, guanethidine, α-methyl-p-tyrosine, diethyldithiocarbamate, 6-hydroxydopamine,
phenoxybenzamine, phentolamine, chlorpromazine and yohimbine markedly inhibited
carrageenin-induced pedal oedema. However, 6-hydroxydopamine given intracerebroventricularly,
5,6-dihydroxytryptamine, p-chlorophenylalanine, lower dose of yohimbine, pro
pranolol, haloperidol, cyproheptadine and mepyramine did not alter the carrageenin-induced
oedema, whereas, cyproheptadine and mepyramine given simultaneously, markedly inhibited
carrageenin-induced oedema. Our studies indicate that the process of oedema formation in
rats by carrageenin involves both the peripheral noradrenaline and 5-hydroxytryptamine.
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Keywords
Carrageenin-induced oedema, noradrenaline-5-hydroxytryptamine-mediators
Citation
Singh P P, Junnarkar A Y, Sridhar D R. Involvement of peripheral noradrenaline and 5-hydroxytryptamine in carrageenin-induced pedal oedema in rats. Journal of Biosciences. 1984 Sept; 6(3): 257-261.