Biological characteristics of a factor suppressing Biological characteristics of a factor suppressing follicle stimulating hormone (inhibin) from ovine testes.
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Date
1983-06
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Abstract
Inhibin (follicle stimulating hormone suppressing factor) isolated from ovine
testes has been characterized for its biological activity using a variety of tests. The bioassay
used – inhibition of the human chorionic gonadotropin induced increment in the mouse
uterine weight– demonstrates that there is a significant increment in specific activity (approx.
300-fold) with the progress of purification. Eventhough the final product has not been
obtained in a homogenous state it has been possible to show that (a) [125I]-labelled inhibin is
preferentially taken up and retained by the pituitary, pretreatment of rats with testosterone
facilitating this uptake; (b) it is able to suppress specifically the levels of follicle stimulating
hormone in castrated as well as immature intact rats and (c) treatment of immature male rats
with inhibin preparation for ten days results in impairment of testicular function as judged by
3H-thymidine incorporation into testicular DNA and testicular hyaluronidase activity.
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Keywords
Regulation of FSH, testicular function, gonadotropin
Citation
Murthy H M Shashidhara, Moudgal N R. Biological characteristics of a factor suppressing Biological characteristics of a factor suppressing follicle stimulating hormone (inhibin) from ovine testes. Journal of Biosciences. 1983 Jun; 5(2): 115-123.