Studies on the uptake of benzanthrone by rat skin and its efflux through serum.
Loading...
Date
1981-12
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The uptake of benzanthrone by rat skin showed saturation kinetics and was
dependent upon the weight of skin and time, temperature and pH of the incubation medium.
Heating of segments above 50°C caused significant lowering of the uptake. The uptake was
irreversibly inhibited by HgCl2 and not by sodium arsenate, KCN, NaF, p-chloromercuriben
zoate, N-ethyl-maleimide, cycloheximide, iodoacetic acid and 2,4-dinitrophenol suggesting
that the uptake was not energy-dependent. Lipid micelles of the skin accounted for a part of
the binding. Most of the benzanthrone taken up by the skin was effluxed through serum
proteins.
Description
Keywords
Benzanthrone, dye intermediate, uptake by the skin, serum transport
Citation
Joshi A, Khanna S K, Singh G B, Murti C R Krishna. Studies on the uptake of benzanthrone by rat skin and its efflux through serum. Journal of Biosciences. 1981 Dec; 3(4): 379-388.