Effect of repeated oral administration of quinalphos to male goat (Capra hircus).
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Date
1982-12
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Abstract
Quinalphos given in daily oral doses of 0.5 mg/kg for 110 days induced severe
signs of organophosphorus poisoning in male goats. The inhibition of acetylcholinesterase
activity in erythrocyte was highly significant. The activity of liver glutamic; oxaloacetic
transaminase, glutamic; pyruvic.transaminase, alkaline phosphatase and protein indicated
marked alteration. The haematological changes were however, relatively less significant with
the exception of a very low count of red blood cells and white blood cells in the treated animals.
Among the vital organs, only liver suggested mild cellular changes due to quinalphos
intoxication. There was no significant pathological change in other organs of the treated
animals.
In animals observed after 15 and 30 days rest, the activity of acetylcholinesterase in red
blood cells and haematological picture showed a fairly good recovery. This study suggests that
although quinalphos in low concentrations did not produce discernible cellular changes, it
induced highly significant enzymatic and haematological changes in the goat.
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Keywords
Organophosphorous, acetylcholinesterase, erythrocyte, quinalphos
Citation
Dikshith T S S, Datta K K, Raizada R B. Effect of repeated oral administration of quinalphos to male goat (Capra hircus). Journal of Biosciences. 1982 Dec; 4(4): 405-411.