Response of blood glucose, hepatic glycogen and pancreatic islets to treatment of sulphydryl inhibitors in Clarias batrachus L.
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Date
1981-09
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Abstract
The correlative effects of the two sulphydryl inhibitors viz., the mono-and dithiol
reagent, alloxan and cobalt chloride, were studied in the fresh water air breathing catfish,
Clarias batrachus. Alloxan induced a typical mammalian-like triphasic response and
necrobiotic changes in the islet β-cells. Cobalt chloride elicited a discontinuous hyperglycemia
with cytopathological changes in β-cells following nearly the same sequence as those
induced by alloxan. However, the α-cells of cobalt-treated fish showed, unlike those after
alloxanization, specific degranulation, vacuolization and nuclear enlargement. The changes
in the hepatic glycogen content of two experimental groups were observed to be equal. Both
the drugs appeared to be detrimental to the normal islet function and were, thus, overtly or
potentially diabetogenic agents to the fish.
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Keywords
Clarias batrachus, islet cells, histophysiology, alloxan, cobalt chloride
Citation
Bhatt Shankar D, Bora Puran S. Response of blood glucose, hepatic glycogen and pancreatic islets to treatment of sulphydryl inhibitors in Clarias batrachus L. Journal of Biosciences. 1981 Sept; 3(3): 259-268.