Interaction of aromatic ionen oligomers with DNA.
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Date
1982-06
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Abstract
A novel polycationic ionen was synthesized and fractionated on carboxymethyl-
Sephadex using a salt gradient in 7M urea. A series of oligomers of discrete length were
characterised by ultraviolet spectra. The ultraviolet spectra of oligomers revealed a new band
centred at 232.5 nm which was probably due to exciton splitting. Thermal denaturation
studies indicated both stabilization of the helix conformation and a higher degree of
cooperativity in the melting of DNA (oligomers)n complex as compared to native calf thymus
DNA. Ionen oligomers exhibited large extrinsic Cotton effect at 232.5 nm which could be
attributed to exciton interaction.
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Keywords
onen-oligomers, DNA, melting temperature, circular dichroism, exciton splitting
Citation
Mulimani V H, Roth A C, Day R A. Interaction of aromatic ionen oligomers with DNA. Journal of Biosciences. 1982 Mar; 4(2): 127-132.