Bacitracin A: Structure-activity relationship.
Loading...
Date
1982-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The single imidazole nucleus of L-histidine residue in bacitracin-A seems to be
important for the anti-bacterial activity of the molecule, since iodination, carboxymethylation
and coupling of diazobenzene sulphonic acid to the histidine residue in the antibiotic caused
90-94% loss of antibacterial activity of the antibiotic. In contrast, the bacitracin sulphone and
sulphoxide derivatives are as active as the parent antibiotic.
Description
Keywords
Bacitracin-A, chemical modification, iodination, carboxymethylation, diazotization
Citation
S Rambhav. Bacitracin A: Structure-activity relationship. Journal of Biosciences. 1982 Mar; 4(1): 25-30.