Arginase from rat fibrosarcoma. Its possible role in proline, glutamate and polyamine metabolism.
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Date
1980-12
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Abstract
The presence of arginase in rat fibrosarcoma not synthesizing urea, suggested that
this enzyme may have additional functions. Ornithine carbamoyl transferase, a key enzyme of the
urea cycle was absent in this tissue, when compared to normal tissues, lower amount of ornithine
was found in the fibrosarcoma, but this tumour contained a higher level of proline. The radioactivity
present in L-[U-14C] arginine was incorporated into putrescine, spermidine, spermine,
proline glutamate and glutamine suggesting that arginine was a possible precursor and that
arginase may have a role in the synthesis of these metabolites.
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Keywords
Rat fibrosarcoma, arginase, ornithine carbamoyl transferase, polyamines, proline, glutamate
Citation
Gopalakrishna R, Nagarajan B. Arginase from rat fibrosarcoma. Its possible role in proline, glutamate and polyamine metabolism. Journal of Biosciences. 1980 Dec; 2(4): 275-282.