A Report On Higher Frequency Of DMD Gene Deletion In The Indian Subcontinent.
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Date
1997-04
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Abstract
Duchenne Muscular Dystrophy (DMD) gene analysis for 25 unrelated patients from Western India using PCR screening for 14 exons and the promoter region was carried out. Intragenic deletions were detected in 18 patients and most of them were located at the 3' hot spot region of the gene indicating that this part of the gene is more deletion prone in the Indian population from Western India as well. The frequency of deletions observed in the present study is 72%.
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Keywords
DMD gene, deletion, India population, promoter region, Exons
Citation
Khalap N V, Joshi V P, Ladiwalla U, Khadilkar S V, Mahajan S K. A Report On Higher Frequency Of DMD Gene Deletion In The Indian Subcontinent. Indian Journal of Human Genetics. 1997 Apr; 3(2): 117-120.