Frequency of Epstein - Barr virus infection as detected by messenger RNA for EBNA 1 in histologically proven gastric adenocarcinoma in patients presenting to a tertiary care center in South India.
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Date
2015-07
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Abstract
Background: Epstein–Barr virus (EBV)‑associated gastric carcinoma is a relatively uncommon entity detected in
approximately 10% of gastric adenocarcinoma. Objective: The purpose of this study is to estimate the frequency of
EBV‑associated gastric carcinoma and also to assess the nature of presentation, any significant difference between
this subgroup and EBV‑negative gastric adenocarcinomas with respect to age and sex predilection, lymph nodal
status, site of presentation. Materials and Methods: We prospectively analyzed 100 cases of gastric adenocarcinoma
who underwent either a partial or total gastrectomy during the period from March 2010 to August 2011. The tumour
and the corresponding normal gastric tissue from the same patient were analyzed for the presence of Epstein–Barr
nuclear antigen 1 (EBNA1) messenger ribonucleic acid (mRNA) by real‑time polymerase chain reaction (PCR).
Result: EBV was detected in 6% cases of gastric adenocarcinoma. All the positive patients were males. The majority of
cases involved the proximal stomach and there was variable lymph nodal involvement. Conclusion: Our study endorses
that there is an association between EBV infection and gastric adenocarcinoma in the Indian population. There was no
significant difference between this subgroup and EBV‑negative gastric adenocarcinomas with respect to age and sex
predilection, lymph nodal status and site of presentation. Short‑term follow‑up of this subgroup of patients seems to
indicate a good overall prognosis after appropriate treatment. However, a larger study with long‑term follow‑up is
needed to further establish the role of EBV in gastric adenocarcinoma in this study population.
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Keywords
EBV, gastric adenocarcinoma, India, PCR
Citation
Rymbai M L, Ramalingam V V, Samarasan I, Chandran B S, Mathew G, Jerobin J, Abraham A M, Sachithanandham J, Kannangai R. Frequency of Epstein - Barr virus infection as detected by messenger RNA for EBNA 1 in histologically proven gastric adenocarcinoma in patients presenting to a tertiary care center in South India. Indian Journal of Medical Microbiology. 2015 Jul-Sept; 33 (3): 369-373.