Oral Squamous Cell Carcinoma in Background of Oral Submucous Fibrosis: A Case Report.
Date
2015-05
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Abstract
Oral submucous fibrosis (OSMF) is a well-recognized, potentially malignant disorder of the oral cavity that can affect any part of the oral
mucosa, characterized by mucosal rigidity of varying intensity caused by fibro elastic transformation of the juxta epithelial layer of connective
tissue. OSMF occurs in Indians and other population of the Indian subcontinent with certain oral habits. Betel quid chewing is a popular oral
habit with potential links to the occurrence of oral cancer. In patients with submucous fibrosis, the oral epithelium becomes atrophic and
thereby becomes more vulnerable to carcinogens. Since the ingredients of betel quid, tobacco are crucial for tumor initiation, promotion and
progression, exposure to these toxicants simultaneously has been shown to markedly potentiate the oral cancer incidence in OSMF patients.
The rate of malignant transformation of OSMF has been estimated to be 2-10%. Most cases with malignant transformation in OSMF have
occurred gradually over a long period of time. This paper presents a case of oral submucous fibrosis turning into malignancy in a 34-year-old
male patient.
Description
Keywords
Areca nut habit, Malignant transformation, Oral squamous cell carcinoma Oral submucous fibrosis
Citation
Balaji P, Govindraju Poornima, Gupta Ashish, Pawar Yogesh, Gazge Nikhat Mukhtar. Oral Squamous Cell Carcinoma in Background of Oral Submucous Fibrosis: A Case Report. IJSS Case Reports & Reviews. 2015 May; 1(12): 40-44.