Reviving the Salivary Cells – Pathway to New Horizon.
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Date
2014-07
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Abstract
The ability to speak, swallow, masticate, taste food, and maintain a healthy oral cavity is heavily reliant on the presence of saliva. Hyposalivation
underlying xerostomia after radiotherapyis still a major problem in the treatment of head and neck cancer. As saliva possesses self-cleansing
and antibacterial capability, hyposalivation is known to deteriorate periodontal status and increases dental disease. Furthermore, hyposalivation
causes mastication and swallowing problems, burning sensation of the mouth and dysgeusia. Currently available treatments for dry mouth are
prescription for artificial saliva, moisturizers, and medications which induce salivation from the residual tissue.2 Such management techniques
do not address the source of the problem that is a lack of functional saliva-producing acinar cells. This review focuses the restoration of
functional salivary glands with advancing modalities such as gene therapy, tissue engineering, and stem cells.
Description
Keywords
Artificial salivary gland, Gene therapy, Stem cells, Tissue engineering
Citation
Hegde Sushmini, Anuradha Ardra, Sodhi Amandeep. Reviving the Salivary Cells – Pathway to New Horizon.IJSS Case Reports & Reviews. 2014 Jul; 1(2): 27-29.