Study of Estradiol, Testosterone and DHEA-S Status in Women After Surgical Menopause.
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Date
2015-03
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Abstract
Aims and Objectives : The study was done to assess
the hormones namely Estradiol, Testosterone, and
Dehydroepiandrosterone-sulphate (DHEAs) one day before
operation and on ninth post-operative day following surgical
menopause. Materials and Methods : This is a cross
sectional observational study. The study was done amongst
the thirty four women aged between 40-48 years with
functioning uterus and at least one ovary, not using any
exogenous hormone preparations affecting ovarian function
for last three months and having at least one menstrual
period in three previous months were included in this study.
They had under gone hysterectomy with bilateral salpingooophorectomy
due to non-ovarian pathology. Fasting
venous blood samples were taken one day before operation
and on ninth post-operative day of surgical menopause
Serum concentration of estradiol, testosterone, and DHEAS
were determined. Results : The circulating estradiol level
decreased significantly (p = 0.043) from 161 pg/ml preoperatively
to 108 pg/ml. on ninth post-operative day after
surgical menopause. In spite of reduction in mean
testosterone level from 0.11 ng/ml. to 0.09 ng/ml. following
surgical menopause, which is statistically insignificant (p
= 0.247).There was no significant difference between the
serum DHEA-S level before and after surgical menopause.
A significant positive correlation was observed between
pre-operative circulatory levels of DHEA-S with that of
estradiol while there was absence of any significant co-relations corelations
between any of the other pairs of values.
Conclusion : The circulating estradiol level decreased
significantly on ninth day after surgical menopause and
significant positive correlation between pre-operative
circulatory levels of DHEA-S with that of estradiol, but
there was no significant co-relation between post-operative
circulating estradiol with that of DHEA-S. Testosterone did
not show any significant relation with estradiol neither in
pre-operative period nor in post-operative condition.
Description
Keywords
surgical menopause, estradiol, testosterone, DHEA-S
Citation
Samanta Subrata, Baral Karabi, Sur Pradyot Kumar. Study of Estradiol, Testosterone and DHEA-S Status in Women After Surgical Menopause. Indian Medical Gazette. 2015 Mar; 149 (3): 89-95.