Antioxidant, antimicrobial activities of flavonoids glycoside from Leucaena leucocephala leaves.
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Date
2015-06
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Abstract
The study aimed to identify the chemical constituents of Leucaeana leucocephala leaves and evaluate the
antioxidant and antimicrobial activities of the extract and compounds. An acylated flavanol glycoside, quercetin -
3-O-(2''-trans-p-coumaryl)-α-rhamnopyranosyl-(1'''→6'')-β-glucopyranoside (1) in addition to quercetin-3-O-α-
rhamnopyranosyl-(1'''→2'')-β–glucopyranoside (2), quercetin-7-O-α–rhamnopyranosyl-(1'''→2'')-β-glucopyrano
side(3), quercetin-3-O-α- rhamnopyranoside(4), quercetin-3-O-β–glucopyranoside (5), isovitexin( 6), vitexin (7)
and quercetin (8) were isolated for the first time from the Leucaeana leucocephala. The antioxidant activity of
the extract and the isolated compounds 1, 3 & 4 were evaluated by Reducing Power, FRAP, DPPH, Metal
chelating and ABTS assays. Compound (3) recorded the highest antioxidant activity in comparison with the
extract and other compounds. The extract and compound 1, 2, 3 and 5 were studied for their antimicrobial
activity. Both the extract and compound 1 have significant activity against gm-ve bacteria, moderate to gm +ve
and Candida and inactive towards fungi. The structures of compounds were elucidated on the basis of spectral
analysis. L. leucocephala possess good antioxidant, antibacterial properties and could serve as free radical
inhibitors or scavengers, acting possibly as primary antioxidants and have to be investigated for antiinflammatory
and anticancer activities.
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Keywords
Leucaeana leucocephala, acylated flavonol glycoside, DPPH, ABTS, FRAP, Metal, chelating, Reducing power, antimicrobial
Citation
Mohammed Reda S, Souda Sahar S El, Taie Hanan A A, Moharam Maysa E, Shaker Kamel H. Antioxidant, antimicrobial activities of flavonoids glycoside from Leucaena leucocephala leaves. Journal of Applied Pharmaceutical Science. 2015 June; 5(6): 138-147.