Design and Optimization of Hydrodynamically Balanced Oral In situ Gel of Glipizide.
Loading...
Date
2015-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: The purpose of the present investigation was to formulate hydrodynamically balanced oral In situ gel
of glipizide inorder to increase the gastric residence time and to modulate the release behavior of the drug.
Material and method: In situgel formulations were prepared by using different concentrations of sodium
alginate, calcium carbonate, trisodium citrate and release retardant polymers. pH triggered ionic gelation is the
mechanism involved in the present study. Taguchi L9 OA experimental design was employed for the
optimization of formulations. All the formulations were subjected to various evaluation parameters. Results:
Formulation F9 containing 3% of sodium alginate, 1.0 % of CaCO3, 0.2% of trisodium citrate and 0.5% of
HPMC-K100M was selected as optimized batch based on Q12 58.26%, floating time 47.76 sec and drug content
98.2%. The release pattern of drug was found to follow first order. The value of ānā from Korsemeyer equation
was found to be 1.00 indicating the drug release by supercase II. The DSC study revealed that there was no
incompatibility. Gastroretentive X-ray imaging study on Albino rabbit demonstrated that it was able to float in
the stomach for more than 8hrs. Pharmacodynamic study on Wistar rats demonstrated significant hypoglycaemic
activity of the optimized formulation. Conclusion: It was concluded that the hydrodynamically balanced oral In
situ gel of glipizide could be an effective dosage form which remains buoyant and sustain the drug release for
24hrs.
Description
Keywords
Hydrodynamically balanced, In situ gel, sodium alginate, gastroretentive
Citation
Swathi G, Lakshmi P K . Design and Optimization of Hydrodynamically Balanced Oral In situ Gel of Glipizide. Journal of Applied Pharmaceutical Science. 2015 May; 5(suppl_1): s31-s38.