Constituents from the Branches of Sambucus sieboldiana var. pendula with the Properties of Collagen Synthesis Activation.
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Date
2015-04
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Abstract
For the purpose of developing anti-wrinkle cosmetic ingredients, the extracts from branches of a woody plant
Sambucus sieboldiana var. pendula were examined on collagen synthesis activities using fibroblast HDFn cells.
As a result, the S. sieboldiana ethanol extract (SSE) proved to activate the production of type I procollagen in a
dose-dependent manner without showing cell toxicity. Phytochemical study was conducted to isolate the active
constituents in the extracts by solvent fractionation followed by chromatographic purifications. From this
procedure, two known compounds, kaempferol 3-O-sophoroside (1) and daucosterol (2), were identified by
spectroscopic studies. From the isolates, the flavonoid glycoside 1 was verified to induce the synthesis of the type
I procollagen dose-dependently. These results suggested that S. sieboldiana extract containing the flavonoid 1
could be useful as an active ingredient in wrinkle-care cosmetics.
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Keywords
Sambucus sieboldiana, collagen, fibroblast, anti-antiwrinkle
Citation
Yim Jun Hwan, Jang Moon Sik, Moon Mi Yeon, Lee Ha Youn, Kim Sung Chun, Lee Nam Ho. Constituents from the Branches of Sambucus sieboldiana var. pendula with the Properties of Collagen Synthesis Activation. Journal of Applied Pharmaceutical Science. 2015 Apr; 5(4): 119-122.