Development of Enteric Coated Sustained Release Matrix Tablets of Sertraline Hydrochloride.
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Date
2015-04
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Abstract
The aim of the present investigation is to develop enteric coated sustained release matrix tablets of Sertraline
hydrochloride (STH) using HPMC K4M and Carbopol-971 as drug release retardants and cellulose acetate
phthalate (CAP) as an enteric coat polymer. The tablets were prepared by direct compression process and
evaluated for various physico-chemical/mechanical parameters. Among the two release retardants, HPMC K4M
was selected based on controlling the STH release during dissolution. The effect of different fillers like
microcrystalline cellulose (MCC), di calcium phosphate (DCP), spray dried lactose with maize starch (SDL) and
pre gelatinized starch (PGS), on STH release was also studied. The percent of STH released at the end of
dissolution with different fillers is in the order of SDL > MCC > DCP > PGS. The tablets containing 15% w/w of
HPMC K4M & MCC as filler with 5% coating weight gain (1% v/v glycerine in 5%w/v CAP solution) gave a
STH release of less than 10% in 0.1N HCl (pH 1.2) for 2 h and a sustained release of STH over a period of 12 h
(99.17±0.54%) in pH 6.8 phosphate buffer and fulfilled the regulatory requirements. The dissolution data was
also evaluated for drug release kinetics and mechanisms.
Description
Keywords
enteric coated tablets, in vitro drug release studies, Sertraline hydrochloride, sustained release
Citation
Uppala Pravallika, shaik Salma, Valluru Saisri Anusha, Nalluri Buchi N. Development of Enteric Coated Sustained Release Matrix Tablets of Sertraline Hydrochloride. Journal of Applied Pharmaceutical Science. 2015 Mar; 5(4): 58-64.