Optimization of the entrapment efficiency and release of ambroxol hydrochloride alginate beads.
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Date
2015-04
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Abstract
The objective of the current study was to optimize the composition of alginate beads to produce ambroxol
hydrochloride alginate beads with optimum specifications. The study employed beads based on sodium alginate
solution (2% w/v) as the main component with calcium chloride solution as crosslinking agent as the prototype
beads. The beads were prepared by syringe method. The effect of viscosity modifiers on the morphology,
entrapment efficiency and drug release was studied. The prototype beads were spherical semitransparent with
entrapment efficiency (EE) of 23%. Incorporation of polyvinylpyrrolidone (PVP) as a viscosity modifier
produced spherical semitransparent beads with higher EE values compared with the prototype. Addition of
carboxymethyl cellulose (CMC) produced oval opaque beads which have larger size and higher EE values
compared with the prototype beads or those containing PVP only. Replacement of CMC with hydroxypropyl
methyl cellulose (HPMC) produced semitransparent spherical beads with significant increase in the EE.
Monitoring the drug release rate from different beads, the all the tested beads were able to retain the drug in the
stomach condition. In the intestinal conditions the release rate depended on the composition of the beads with
prototype beads librating most of its contents in the first 15 minutes. Formulations containing either CMC or
HPMC were able to retard the drug release in the intestinal phase. In conclusion the study developed beads with
optimum entrapment and release of ambroxol hydrochloride.
Description
Keywords
alginate beads, specification, viscosity modifiers, E E, release
Citation
Abdalla Karam F, Kamoun Elabadawy A, Maghraby Gamal M El. Optimization of the entrapment efficiency and release of ambroxol hydrochloride alginate beads. Journal of Applied Pharmaceutical Science. 2015 Mar; 5(4): 13-19.