OCD and Bacterial Infection: Is there a link.
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Date
2010-04
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Abstract
The data which addresses the validity of the proposed unique subgroup of children with
early and abrupt onset of obsessive-compulsive disorder (OCD) and/or tic disorder
subsequent to streptococcal infection was reviewed. The aetiology of OCD and tic disorder
is unknown, although it appears that both disorders may arise from a variety of genetic
and environmental factors. Post-streptococcal autoimmunity has been postulated as one
such mechanism. Although much research remains to be done, an increasing body of
evidence provides support for the postulate that OCD may arise from post-streptococcal
autoimmunity. The unique clinical characteristic of the PANDAS sub group, the presence
of volumetric changes in basal ganglia and the dramatic response to immunomodulatory
treatment suggest that symptoms arise from a combination of local, regional and systemic
dysfunction and further research is required in order to provide novel strategies of
prevention and treatment.
Description
Keywords
OCD, bacterial infection
Citation
Malhotra Shalini, Kaur Nirmaljit, Hans Charoo, Bhatia M S. OCD and Bacterial Infection: Is there a link. Delhi Psychiatry journal. 2010 Apr; 13 (1): 134-136.