Cytotoxic compounds from the leaves of Garcinia cowa Roxb.
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Date
2015-02
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Abstract
The aims of this study was to isolate compounds from the leaves of methanol extract of Garcinia cowa and to
evaluated their cytotoxic activity against breast (MCF-7) and lung (H-460) cell lines. The dichloromethane
fraction was separated by successive silica gel column chromatography to give three compounds. Based on
spectroscopic comparison with those of the literature these compounds were elucidated as methyl 2,4,6-
trihydroxy-3-(3-methylbut-2-enyl)benzoate (1), garcinisidone-A (2) and methyl 4,6dihydroxy-2-(4-methoxy-5-
(3-methylbut-2-enyl)-3,6-dioxocylohexa-1,4-dienyloxy)-3-(3-methylbut-2-enyl)benzoate (3). Compound 1, 2 and
3 had IC50 value of 21.0 ± 10.2 μM, 21.2 ±8.4 μM and 17.2 ± 6.2μM against MCF-7, while only compound (2)
was found to be in active against H-460 with IC50 value of 18.1 ± 6.7 μM. Conclusion: The results indicate that
G. cowa leaves could be important sources of natural cytotoxic compounds and only compound (2) had activity
against H-460 cell lines.
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Keywords
Structure elucidation, NMR, spectroscopy, xanthone, benzoate, Garcinia cowa Roxb, cytotoxic activity, MCF-7, H-460
Citation
Wahyuni Fatma Sri, Shaari Khozirah, Stanslas Johnson, Lajis Nordin, Hamidi Dachriyanus. compounds from the leaves of Garcinia cowa Roxb. Journal of Applied Pharmaceutical Science. 2015 Feb; 5(2): 6-11.