Characterization of Encapsulation Process of Avobenzone in Solid Lipid Microparticle Using a Factorial Design and its Effect on Photostability.
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Date
2014-12
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Abstract
Avobenzone (AVO)liposphereswere obtained using as encapsulating material carnauba wax and applying the
method of hot emulsification. A factorial design 23 was performed to optimize and recognize the influence of the
initial amount of AVO, the stearyl alcohol (SA) and polysorbate (PS-20)concentrationsin the AVO loading, mean
and D90 particle size. The results showed a variation of AVO loading between 1.8 and 20%, which was mainly
affected by initial amount of AVO. The mean particle size D [4.3] ranged from 11.11 to 37.15 μm, this was
affected by the levels of SA and PS-20, while D90 was influenced by three variables under study. Lipospheres
highly loaded and under a narrow particle distribution was obtained when initial amount of AVO, SA and PS-20
were set in the maximum level. The study showed that the encapsulation process enhanced the photostability
going from 31.5% for free AVO to 16.2% for the encapsulated AVO.
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Keywords
Avobenzone, solid lipid microparticles, lipospheres, photodegradation
Citation
Cabrera Cecilia Gallardo, Madrid Juan Fernando Pinillos, Arteaga Jhonathan David Pazmiño, Alejandro Munera Echeverry. Characterization of Encapsulation Process of Avobenzone in Solid Lipid Microparticle Using a Factorial Design and its Effect on Photostability. Journal of Applied Pharmaceutical Science. 2014 Dec; 4(12): 35-43.