Enhancing Solubility and Dissolution of Olanzapine by Spray Drying Using β- Cyclodextrin Polymer.
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Date
2014-11
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Abstract
Olanzapine, an antipsychotic agent, exhibits poor water solubility, dissolution and flow properties. Thus, the aim
of the present study was to improve the solubility and dissolution rate of Olanzapine by preparing microspheres
by spray drying technique using β-cyclodextrin. Olanzapine Microspheres containing different ratios of β-
cyclodextrin were produced by spray drying using Propanol and water (50:50) as solvent system to enhance
solubility and dissolution rate. The prepared formulations containing different ratios of drug and β-cyclodextrin
were evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by DSC, FTIR,
XRD and SEM. Dissolution profile of the prepared spray dried microspheres was compared with its physical
mixture and pure sample. Spray dried microspheres exhibited decreased crystallinity. The solubility of
microspheres containing Olanzapine and β-cyclodextrin (1:3w/w) exhibited tenfold increases than the
commercial Olanzapine and dissolution of same ratio microsphere showed 99 % release in 20 min. while same
composition in physical mixture showed 37% release in 20 min. Consequently, from the above result it can be
concluded that spray dried microspheres of Olanzapine is a useful technique to improve the solubility and
dissolution of poor water soluble drug like Olanzapine.
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Keywords
Spray drying, microspheres, Olanzapine, β-cyclodextrin, solubility, dissolution
Citation
Dixit Mudit, Charyulu R Narayana, Shetty Anupama, Charyalu Narayana, Rao Meghana, Bengre Pallavi. Enhancing Solubility and Dissolution of Olanzapine by Spray Drying Using β- Cyclodextrin Polymer. Journal of Applied Pharmaceutical Science. 2014 Nov; 4(11): 81-86.